Limk1^tm1Zpj
Targeted Allele Detail

Summary

• Symbol: Limk1^tm1Zpj
• Name: LIM domain kinase 1; targeted mutation 1, Zhengping Jia
• MGI ID: MGI:2679321
• Synonyms: LIMK-1^-
• Gene: Limk1 Location: Chr5:134684893-134717452 bp, - strand Genetic Position: Chr5, 74.73 cM, cytoband G2
• Alliance: Limk1^tm1Zpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86283
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exons containing the second LIM domain and the PDZ domain were replaced with a PGK-neo cassette. In resulting homozygotes, no mRNA expression or protein product was detected. (J:86283)

Disease models

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Limk1 Mutation: 28 strains or lines available

References

• Original: J:86283 Meng Y, et al., Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron. 2002 Jul 3;35(1):121-33
• All: 16 reference(s)