Fos^tm7Wag
Targeted Allele Detail

Summary

• Symbol: Fos^tm7Wag
• Name: FBJ osteosarcoma oncogene; targeted mutation 7, Erwin F Wagner
• MGI ID: MGI:2679338
• Synonyms: c-fos^f, Fos^tm1Pga
• Gene: Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
• Alliance: Fos^tm7Wag page

Reduced tumor growth in Fos^tm7Wag/Fos^tm7Wag Tg(Cd4-cre)1Cwi/0 mice following carcinoma cell inoculation

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85928
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the first intron and a PGK neomycin cassette flanked by flp sites was inserted along with a second loxP site downstream of the polyadenylation signal. Still further downstream, a splice acceptor was placed just 5' to an EGFP gene insert. The PGK neo construct was deleted in vivo using flip recombinase transgenic mice. (J:85928)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fos Mutation: 43 strains or lines available

References

• Original: J:85928 Fleischmann A, et al., Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci. 2003 Oct 8;23(27):9116-22
• All: 19 reference(s)