Arnt^tm1.2Gonz
Targeted Allele Detail

Summary

• Symbol: Arnt^tm1.2Gonz
• Name: aryl hydrocarbon receptor nuclear translocator; targeted mutation 1.2, Frank Gonzalez
• MGI ID: MGI:2679362
• Synonyms: Arnt^delta
• Gene: Arnt Location: Chr3:95341699-95404551 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Arnt^tm1.2Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85934
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site remained in place of exon 6 after the floxed region encompassing a neo cassette and exon 6 was excised from Arnt^tm1Gonz via cre mediated recombination in the germline. (J:85934)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arnt Mutation: 65 strains or lines available

References

• Original: J:85934 Tomita S, et al., T cell-specific disruption of arylhydrocarbon receptor nuclear translocator (Arnt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution. J Immunol. 2003 Oct 15;171(8):4113-20
• All: 3 reference(s)