Drd2^{tm1(IL2RA)Koba}
Targeted Allele Detail

Summary

• Symbol: Drd2^{tm1(IL2RA)Koba}
• Name: dopamine receptor D2; targeted mutation 1, Kazuto Kobayashi
• MGI ID: MGI:2679435
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^{tm1(IL2RA)Koba} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85929
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human IL2RA gene was inserted into exon 2 of the endogenous locus. Thet targeting construct included a polyadenylation signal and neo gene immediately downstream of IL2RA. Treatment of mutant mice with a recombinant immunotoxin consisting of the variable regions of the anti-IL2RA monoclonal antibody fused to a bacterial exotoxin results in the specific ablation of cells expressing IL2RA via the Drd2 promoter. (J:85929)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:85929 Sano H, et al., Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function. J Neurosci. 2003 Oct 8;23(27):9078-88
• All: 3 reference(s)