Kcna3^tm1Lys
Targeted Allele Detail

Summary

• Symbol: Kcna3^tm1Lys
• Name: potassium voltage-gated channel, shaker-related subfamily, member 3; targeted mutation 1, Lyanne C Schlichter
• MGI ID: MGI:2679440
• Synonyms: Kv1.3-
• Gene: Kcna3 Location: Chr3:106943485-106945386 bp, + strand Genetic Position: Chr3, 46.59 cM
• Alliance: Kcna3^tm1Lys page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85937
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promotor region and the 5' end of the coding region were replaced by a neomycin resistance gene in inverse orientation. Absence of mRNA transcripts was demonstrated by RT-PCR and absence of protein product by Western blot. (J:85937)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcna3 Mutation: 22 strains or lines available

References

• Original: J:85937 Koni PA, et al., Compensatory anion currents in Kv1.3 channel-deficient thymocytes. J Biol Chem. 2003 Oct 10;278(41):39443-51
• All: 15 reference(s)