Pnoc^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Pnoc^tm1Jep
• Name: prepronociceptin; targeted mutation 1, John E Pintar
• MGI ID: MGI:2679470
• Gene: Pnoc Location: Chr14:65638931-65662908 bp, - strand Genetic Position: Chr14, 34.33 cM, cytoband D1
• Alliance: Pnoc^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85899
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exon 3 coding sequence was replaced with a neomycin selection cassette inserted by homologous recombination. Homozygous mutant mice lacked immunoreactivity. (J:85899)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnoc Mutation: 13 strains or lines available

References

• Original: J:85899 Kest B, et al., Morphine tolerance and dependence in nociceptin/orphanin FQ transgenic knock-out mice. Neuroscience. 2001;104(1):217-22
• All: 2 reference(s)