Nr1h4^tm1Kok
Targeted Allele Detail

Summary

• Symbol: Nr1h4^tm1Kok
• Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1, Tineke Kok
• MGI ID: MGI:2679472
• Synonyms: Fxr^-
• Gene: Nr1h4 Location: Chr10:89290096-89369447 bp, - strand Genetic Position: Chr10, 44.98 cM
• Alliance: Nr1h4^tm1Kok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86154
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. Transcript was undetected by Northern blot analysis of hepatic RNA obtained from homozygous mutant mice. (J:86154)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h4 Mutation: 43 strains or lines available

References

• Original: J:86154 Kok T, et al., Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem. 2003 Oct 24;278(43):41930-7
• All: 7 reference(s)