Slit3^{Gt(OST106158)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Slit3^{Gt(OST106158)Lex}
• Name: slit guidance ligand 3; gene trap OST106158, Lexicon Genetics
• MGI ID: MGI:2679499
• Synonyms: Slit3^Gt1Hhu
• Gene: Slit3 Location: Chr11:35012283-35599334 bp, + strand Genetic Position: Chr11, 20.29 cM, cytoband A5
• Alliance: Slit3^{Gt(OST106158)Lex} page

Mutation origin

• Mutant Cell Line: OST106158
• Germline Transmission: Earliest citation of germline transmission: J:86149
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The endogenous locus was disrupted by gene trap mutation. RT-PCR analysis of homozygous mutant mice indicated transcript levels were reduced to less than 1.5% of those of wild-type mice. (J:86149)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST106158	CG527790 ; (MGI Seq Detail)	3' RACE	Chr11:35435575-35461546 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  28 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slit3 Mutation: 81 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:86149 Liu J, et al., Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mech Dev. 2003 Sep;120(9):1059-70
• All: 3 reference(s)