Guca2b^tm1Lorz
Targeted Allele Detail

Summary

• Symbol: Guca2b^tm1Lorz
• Name: guanylate cyclase activator 2b; targeted mutation 1, John N Lorenz
• MGI ID: MGI:2679505
• Synonyms: Ugn^-, UGN-
• Gene: Guca2b Location: Chr4:119513798-119516142 bp, - strand Genetic Position: Chr4, 55.48 cM
• Alliance: Guca2b^tm1Lorz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86148
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from the kidney and a variety of intestinal tissues. The absence of protein was confirmed by Western blot analysis. (J:86148)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Guca2b Mutation: 7 strains or lines available

References

• Original: J:86148 Lorenz JN, et al., Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. J Clin Invest. 2003 Oct;112(8):1244-54
• All: 5 reference(s)