Fas^tm1Vbo
Targeted Allele Detail

Summary

• Symbol: Fas^tm1Vbo
• Name: Fas cell surface death receptor; targeted mutation 1, Harald von Boehmer
• MGI ID: MGI:2679555
• Synonyms: fas^fl
• Gene: Fas Location: Chr19:34268066-34305172 bp, + strand Genetic Position: Chr19, 29.48 cM
• Alliance: Fas^tm1Vbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85985
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 9, the death domain encoding exon, was flanked by single loxP sites. (J:85985)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fas Mutation: 82 strains or lines available

References

• Original: J:85985 Apostolou I, et al., Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med. 2003 Oct 6;198(7):1103-6
• All: 4 reference(s)