Tg(MMTV-PyVT)634Mul
Transgene Detail

Summary

• Symbol: Tg(MMTV-PyVT)634Mul
• Name: transgene insertion 634, William Muller
• MGI ID: MGI:2679595
• Synonyms: MMTV-PyMT, MMTV-PyVmT, MT634, MTAG, PyMT, PyV-mT, PyVT, Tg(MMTVPyVT)634Mul, TgN(MMTVPyVT)^634Mul, TgN(MMTVPyVT)634Mul
• Transgene: Tg(MMTV-PyVT)634Mul Location: unknown
• Alliance: Tg(MMTV-PyVT)634Mul page

A basal-like subtype of mammary tumors in Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0 mice

Show the 4 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene expresses polyoma virus middle T antigen under the control of the mouse mammary tumor virus LTR. Expression of this transgene was detected at high levels in male and female mammary glands. Other expression sites include salivary gland, seminal vesicles, ovaries, and lung. (J:46460)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-PyVT)634Mul

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Additional lines produced include lines 121, 196, 235, 654, 668, 670.

These mice are used to study metastatic disease.

References

• Original: J:46460 Guy CT, et al., Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol. 1992 Mar;12(3):954-61
• All: 610 reference(s)