Cplx1^tm2Bros
Targeted Allele Detail

Summary

• Symbol: Cplx1^tm2Bros
• Name: complexin 1; targeted mutation 2, Nils Brose
• MGI ID: MGI:2679624
• Synonyms: Cplx1^-, Cplx1^tm1Rmnd, CPX I-
• Gene: Cplx1 Location: Chr5:108666420-108697890 bp, - strand Genetic Position: Chr5, 53.17 cM
• Alliance: Cplx1^tm2Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86365
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was replaced by a neomycin resistance gene. Western blot analysis of adult brains demonstrated the abolition of protein product expression. (J:86365)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cplx1 Mutation: 13 strains or lines available

References

• Original: J:86365 Reim K, et al., Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell. 2001 Jan 12;104(1):71-81
• All: 18 reference(s)