Plcl2^tm1Tta
Targeted Allele Detail

Summary

• Symbol: Plcl2^tm1Tta
• Name: phospholipase C-like 2; targeted mutation 1, Tadaomi Takenawa
• MGI ID: MGI:2679632
• Synonyms: PLC-L2^-, PRIP-2 KO
• Gene: Plcl2 Location: Chr17:50816431-50995512 bp, + strand Genetic Position: Chr17, 25.86 cM, cytoband C
• Alliance: Plcl2^tm1Tta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85960
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a cassette containing a neomycin resistance gene. The deleted exon encoded the pleckstrin homology domain, the X-Y domain, and the C2 domain. Protein was undetected in homozygous mutant mice by Western blot analysis of spleen extracts. (J:85960)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcl2 Mutation: 51 strains or lines available

References

• Original: J:85960 Takenaka K, et al., Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Mol Cell Biol. 2003 Oct;23(20):7329-38
• All: 15 reference(s)