Pak4^tm1Amin
Targeted Allele Detail

Summary

• Symbol: Pak4^tm1Amin
• Name: p21 (RAC1) activated kinase 4; targeted mutation 1, Audrey Minden
• MGI ID: MGI:2679635
• Synonyms: PAK4^-
• Gene: Pak4 Location: Chr7:28258244-28297609 bp, - strand Genetic Position: Chr7, 16.84 cM
• Alliance: Pak4^tm1Amin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85954
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, containing the initiating methionine and the critical GTPase-binding domaain, was replaced with a PGK-neo cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analysis of homozygous mutant brain tissue. (J:85954)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pak4 Mutation: 94 strains or lines available

Notes

ES cell line = D3 or E14.

References

• Original: J:85954 Qu J, et al., PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct;23(20):7122-33
• All: 3 reference(s)