Pak5^tm1Amin
Targeted Allele Detail

Summary

• Symbol: Pak5^tm1Amin
• Name: p21 (RAC1) activated kinase 5; targeted mutation 1 Audrey Minden
• MGI ID: MGI:2679653
• Synonyms: PAK5^-
• Gene: Pak5 Location: Chr2:135923024-136229887 bp, - strand Genetic Position: Chr2, 67.32 cM
• Alliance: Pak5^tm1Amin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85956
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of homozygous mutant brain extracts. (J:85956)

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pak5 Mutation: 38 strains or lines available

References

• Original: J:85956 Li X, et al., Targeted disruption of the gene for the PAK5 kinase in mice. Mol Cell Biol. 2003 Oct;23(20):7134-42
• All: 4 reference(s)