Syvn1^tm1Tn
Targeted Allele Detail

Summary

• Symbol: Syvn1^tm1Tn
• Name: synovial apoptosis inhibitor 1, synoviolin; targeted mutation 1, Toshihiro Nakajima
• MGI ID: MGI:2679656
• Synonyms: syno^+/-, synoviolin/hrd1^+/-
• Gene: Syvn1 Location: Chr19:6096606-6103742 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband A
• Alliance: Syvn1^tm1Tn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86009
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing lacZ and neo was inserted at the start codon located in exon 1. Northern and Western blot analyses of homozygous mutant embryos indicated an absence of both transcript and protein. (J:86009)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syvn1 Mutation: 27 strains or lines available

References

• Original: J:86009 Amano T, et al., Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 2003 Oct 1;17(19):2436-49
• All: 4 reference(s)