Kat6b^{Gt(pKC199)1Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Kat6b^{Gt(pKC199)1Pgr}
• Name: K(lysine) acetyltransferase 6B; gene trap 1, Peter Gruss
• MGI ID: MGI:2679726
• Synonyms: qkf^gt, querkopf^gt
• Gene: Kat6b Location: Chr14:21549284-21722546 bp, + strand Genetic Position: Chr14, 11.73 cM
• Alliance: Kat6b^{Gt(pKC199)1Pgr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62161
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The insertion of a gene trap vector into a 5' untranslated exon resulted in a hypomorphic allele from which normal coding mRNA is produced at a level approximately 10% that of the wild-type. The insertion site corresponds with base 76 of the cDNA. (J:62161)

Disease models

Expression

In Mice Carrying this Mutation:	33 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat6b Mutation: 108 strains or lines available

References

• Original: J:62161 Thomas T, et al., Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development. Development. 2000 Jun;127(12):2537-48
• All: 5 reference(s)