Zbtb17^tm1Elr
Targeted Allele Detail

Summary

• Symbol: Zbtb17^tm1Elr
• Name: zinc finger and BTB domain containing 17; targeted mutation 1, Martin Eilers
• MGI ID: MGI:2679766
• Synonyms: Miz1^-
• Gene: Zbtb17 Location: Chr4:141171984-141195248 bp, + strand Genetic Position: Chr4, 74.17 cM, cytoband E1
• Alliance: Zbtb17^tm1Elr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86265
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment encompassing exons 3 through 5, which are the first 3 coding exons, as well as was 2 kb of sequence upstream of exon 3. Neither mutant transcript nor protein was detected by RT-PCR and Western blot analyses of heterozygous mutant mice. (J:86265)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb17 Mutation: 43 strains or lines available

References

• Original: J:86265 Adhikary S, et al., Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol. 2003 Nov;23(21):7648-57
• All: 3 reference(s)