Tsix^tm1Enl
Targeted Allele Detail

Summary

• Symbol: Tsix^tm1Enl
• Name: X (inactive)-specific transcript, opposite strand; targeted mutation 1, En Li
• MGI ID: MGI:2679786
• Synonyms: Tsix^AA2delta1.7, X^deltaTsix
• Gene: Tsix Location: ChrX:102475123-102528563 bp, + strand Genetic Position: ChrX, 46.13 cM
• Alliance: Tsix^tm1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68136
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with an IRES Beta-geo cassette. Northern blot analysis demonstrated that no mRNA transcripts were produced as opposed to interruption of exon 1 alone which had little affect on expression in ES cells. (J:68136)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tsix Mutation: 57 strains or lines available

References

• Original: J:68136 Sado T, et al., Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development. 2001 Apr;128(8):1275-86
• All: 7 reference(s)