Ticam1^Lps2
Chemically induced Allele Detail

Summary

• Symbol: Ticam1^Lps2
• Name: TIR domain containing adaptor molecule 1; lipopolysaccharide 2
• MGI ID: MGI:2679794
• Synonyms: Lps, Lps2, Lps2-, Ticam1^-, Ticam1^M1Btlr, TRIF-, Trif^Lps2, Trif^m
• Gene: Ticam1 Location: Chr17:56576462-56583767 bp, - strand Genetic Position: Chr17, 29.24 cM
• Alliance: Ticam1^Lps2 page

Decreased susceptibility to induced colitis in Ticam1^Lps2/Ticam1^Lps2 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: ENU mutagenesis induced the deletion of a single guanine within codon 708, resulting in a frameshift mutation. The mutation was predicted to replace 24 C-terminal residues with 11 unrelated residues. The mutation was initially detected by screening macrophages for their competence to respond to LPS. (J:84896, J:86521)
• Inheritance: Codominant

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ticam1 Mutation: 54 strains or lines available

References

• Original: J:86521 Hoebe K, et al., Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res. 2003;9(4):250-5
• All: 305 reference(s)