Pten^tm2Ppp
Targeted Allele Detail

Summary

• Symbol: Pten^tm2Ppp
• Name: phosphatase and tensin homolog; targeted mutation 2, Pier Paolo Pandolfi
• MGI ID: MGI:2679885
• Synonyms: Pten^hy, Pten^hypo
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm2Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86212
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A hypomorphic allele was generated by the insertion of a floxed CMV-neo cassette into intron 3. A single loxP site was inserted into intron 5, thereby flanking exons 4 and 5 with loxP sites. (J:86212)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm2Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:86212 Trotman LC, et al., Pten Dose Dictates Cancer Progression in the Prostate. PLoS Biol. 2003 Dec;1(3):385-96
• All: 5 reference(s)