Cdk2^tm1Kald
Targeted Allele Detail

Summary

• Symbol: Cdk2^tm1Kald
• Name: cyclin dependent kinase 2; targeted mutation 1, Philipp Kaldis
• MGI ID: MGI:2679913
• Synonyms: Cdk2^-
• Gene: Cdk2 Location: Chr10:128533808-128540900 bp, - strand Genetic Position: Chr10, 77.13 cM, cytoband D3
• Alliance: Cdk2^tm1Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86203
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neomycin resistance gene flanked by FRT sites. In spite of truncated transcript consisting of exons 1 through 3 detected by RT-PCR analysis, neither protein nor kinase activity was detected in samples obtained from homozygous mutant mice. (J:86203)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdk2^tm1Kald

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk2 Mutation: 18 strains or lines available

References

• Original: J:86203 Berthet C, et al., Cdk2 knockout mice are viable. Curr Biol. 2003 Oct 14;13(20):1775-85
• All: 21 reference(s)