Id1^tm1Zhu
Targeted Allele Detail

Summary

• Symbol: Id1^tm1Zhu
• Name: inhibitor of DNA binding 1, HLH protein; targeted mutation 1, Yuan Zhuang
• MGI ID: MGI:2679939
• Synonyms: Id1-
• Gene: Id1 Location: Chr2:152578171-152579330 bp, + strand Genetic Position: Chr2, 75.41 cM
• Alliance: Id1^tm1Zhu page

Osteoporotic phenotype of 6 week old Id1^tm1Zhu/Id1^tm1Zhu mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44278
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exon 1 and part of the promoter sequence were replaced with a PGK neomycin resistance cassette. Disruption was confirmed by Northern blot analysis. (J:44278)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Id1 Mutation: 10 strains or lines available

References

• Original: J:44278 Yan W, et al., High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. Mol Cell Biol. 1997 Dec;17(12):7317-27
• All: 38 reference(s)