Arx^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Arx^tm1Pgr
• Name: aristaless related homeobox; targeted mutation 1, Peter Gruss
• MGI ID: MGI:2679972
• Gene: Arx Location: ChrX:92330113-92341963 bp, + strand Genetic Position: ChrX, 41.05 cM
• Alliance: Arx^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86206
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a cassette containing lacZ followed by floxed neo. The deleted sequence encodes 360 N-terminal residues which make up the octapeptide (Eh1 domain), alpha-helix 1, and approximately half of alpha-helix 2 homeodomain. Normal transcript was undetected by in situ hybridization of neural tube sections obtained from hemizygous fetuses. LacZ expression was detected. (J:86206)

Expression

In Mice Carrying this Mutation:	17 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arx Mutation: 20 strains or lines available

References

• Original: J:86206 Collombat P, et al., Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev. 2003 Oct 15;17(20):2591-603
• All: 14 reference(s)