Stub1^tm1Cpat
Targeted Allele Detail

Summary

• Symbol: Stub1^tm1Cpat
• Name: STIP1 homology and U-Box containing protein 1; targeted mutation 1, Cam Patterson
• MGI ID: MGI:2680005
• Synonyms: CHIP (-)
• Gene: Stub1 Location: Chr17:26049608-26051893 bp, - strand Genetic Position: Chr17, 12.93 cM, cytoband B1
• Alliance: Stub1^tm1Cpat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis. (J:86213)

Disease models

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Stub1 Mutation: 21 strains or lines available

References

• Original: J:86213 Dai Q, et al., CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J. 2003 Oct 15;22(20):5446-58
• All: 21 reference(s)