Iglc1^tm1Ust
Targeted Allele Detail

Summary

• Symbol: Iglc1^tm1Ust
• Name: immunoglobulin lambda constant 1; targeted mutation 1, Ursula Storb
• MGI ID: MGI:2680012
• Synonyms: Igl^tm1Ust, S-n
• Gene: Iglc1 Location: Chr16:18880502-18880821 bp, - strand Genetic Position: Chr16, 11.8 cM
• Alliance: Iglc1^tm1Ust page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68144
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP flanked neomycin selection cassette was inserted 100 bp upstream of the Jlambda1 recombination signal sequence. In addition, two point mutations were introduced that altered codon 154 of the Clambda1 region from one that encodes glycine to one encoding serine (G154S). (J:68144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iglc1 Mutation: 4 strains or lines available

References

• Original: J:68144 Sun T, et al., Insertion of phosphoglycerine kinase (pgk)-neo 5' of jlambda1 dramatically enhances vjlambda1 rearrangement. J Exp Med. 2001 Mar 19;193(6):699-712
• All: 2 reference(s)