Dapp1^tm1Mnz
Targeted Allele Detail

Summary

• Symbol: Dapp1^tm1Mnz
• Name: dual adaptor for phosphotyrosine and 3-phosphoinositides 1; targeted mutation 1, Michel C Nussenzweig
• MGI ID: MGI:2680020
• Synonyms: Bam32-
• Gene: Dapp1 Location: Chr3:137636768-137687306 bp, - strand Genetic Position: Chr3, 63.98 cM, cytoband H2
• Alliance: Dapp1^tm1Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86182
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette. Neither normal transcript nor aberrant splice products were detected by RT-PCR analysis. Protein was undetected by Western blot analysis of extracts of homozygous mutant splenic B cells. (J:86182)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dapp1 Mutation: 28 strains or lines available

References

• Original: J:86182 Han A, et al., Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. Immunity. 2003 Oct;19(4):621-32
• All: 9 reference(s)