Acvrl1^tm1Spo
Targeted Allele Detail

Summary

• Symbol: Acvrl1^tm1Spo
• Name: activin A receptor, type II-like 1; targeted mutation 1, S Paul Oh
• MGI ID: MGI:2680088
• Synonyms: Alk1^lacZ
• Gene: Acvrl1 Location: Chr15:101026403-101043217 bp, + strand Genetic Position: Chr15, 56.41 cM, cytoband F3
• Alliance: Acvrl1^tm1Spo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85877
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 to 8 were replaced with an IRES-lacZ/PKGneomycin cassette. The transmembrane domain coded by exon 5 is thus eliminated. (J:85877)

Expression

In Mice Carrying this Mutation:

34 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvrl1 Mutation: 27 strains or lines available

References

• Original: J:85877 Seki T, et al., Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res. 2003 Oct 3;93(7):682-9
• All: 4 reference(s)