Tgfbr1^tm1.1Karl
Targeted Allele Detail

Summary

• Symbol: Tgfbr1^tm1.1Karl
• Name: transforming growth factor, beta receptor I; targeted mutation 1.1, Stefan Karlsson
• MGI ID: MGI:2680164
• Synonyms: Alk5^Flox, Alk5^loxP, Tgfbr1^f
• Gene: Tgfbr1 Location: Chr4:47353258-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
• Alliance: Tgfbr1^tm1.1Karl page

Tgfbr1^tm1.1Karl/Tgfbr1^tm1.1Karl Pten^tm1Hwu/Pten^tm1Hwu Tg(KRT14-cre/ERT)20Efu/0 mice develop anal squamous cell carcinoma

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86262
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was left flanked by single loxP sites after the removal of an upstream floxed neo cassette by the transient expression of cre recombinase in ES cells. (J:86262)

Disease models

Expression

In Mice Carrying this Mutation:	102 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfbr1^tm1.1Karl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tgfbr1 Mutation: 36 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or GS (129S6/SvEvTac).

References

• Original: J:68770 Larsson J, et al., Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J. 2001 Apr 2;20(7):1663-73
• All: 108 reference(s)