Rnf111^{Gt(Betageo)1Vep}
Gene trapped Allele Detail

Summary

• Symbol: Rnf111^{Gt(Betageo)1Vep}
• Name: ring finger 111; gene trap 1, Vasso Episkopou
• MGI ID: MGI:2680166
• Synonyms: arkadia -
• Gene: Rnf111 Location: Chr9:70332706-70411007 bp, - strand Genetic Position: Chr9, 39.53 cM
• Alliance: Rnf111^{Gt(Betageo)1Vep} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68833
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector inserted into an intron near the 5' end of the gene. The transcript expressed from this allele fuses 5' UTR elements of the endogenous gene to the beta-galactosidase/neomycin gene fusion in the inserted gene trap vector. No endogenous intact transcript was detectable by in situ hybridization, northern blot or RT-PCR analysis on homozygous embryos. (J:68833)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf111 Mutation: 325 strains or lines available

Notes

When tetraploid wild-type embryos are aggregated with mutant ES cells to generate chimeras with wild-type extraembryonic lineages, all chimeric embyros develop normal heads and mesoderm indicating Rnf111 function is required in extraembryonic lineages for normal development.

References

• Original: J:68833 Episkopou V, et al., Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001 Apr 12;410(6830):825-30
• All: 3 reference(s)