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Tg(Tcra/Tcrb)1Vbo
Transgene Detail
Summary
Symbol: Tg(Tcra/Tcrb)1Vbo
Name: transgene insertion 1, Harald von Boehmer
MGI ID: MGI:2680176
Synonyms: 6.5 TcR, HA TCR, SFE TCR, TCR-HA, TCR-SFE, TS1
Transgene: Tg(Tcra/Tcrb)1Vbo  Location: unknown  
Alliance: Tg(Tcra/Tcrb)1Vbo page
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcra/Tcrb)1Vbo expresses 2 genes
 
Mutation detailsThe transgenic construct expresses a T cell receptor specific for peptide 111-119 from influenza hemagglutinin (HA), presented by class II I-Ed MHC molecules. The receptor is encoded by Tcrb-V8.2, Tcrb-J, Tcra-V4, and Tcra-J. (J:86429)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
show or hide all annotated terms
             
cardiovascular system
heart inflammation
hematopoietic system
increased double-positive T cell number
decreased regulatory T cell number
increased regulatory T cell number
abnormal CD4-positive, alpha beta T cell morphology
decreased CD4-positive, alpha-beta T cell number
increased IgG level
abnormal regulatory T cell physiology
homeostasis/metabolism
abnormal circulating cytokine level
increased circulating interleukin-6 level
immune system
heart inflammation
increased double-positive T cell number
decreased regulatory T cell number
increased regulatory T cell number
abnormal CD4-positive, alpha beta T cell morphology
decreased CD4-positive, alpha-beta T cell number
increased IgG level
abnormal regulatory T cell physiology
abnormal circulating cytokine level
increased circulating interleukin-6 level
increased susceptibility to autoimmune diabetes
joint inflammation
autoimmune arthritis
kidney inflammation
renal/urinary system
kidney inflammation
respiratory system
abnormal lung morphology
skeleton
joint inflammation
autoimmune arthritis
abnormal articular cartilage morphology
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
cn1
cx5
IDs
IDs
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:86429 Kirberg J, et al., Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med. 1994 Jul 1;180(1):25-34
All:  98 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory