Trp53tm1Xu
Targeted Allele Detail
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Symbol: |
Trp53tm1Xu |
Name: |
transformation related protein 53; targeted mutation 1, Yang Xu |
MGI ID: |
MGI:2680218 |
Synonyms: |
p53S18A |
Gene: |
Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
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Alliance: |
Trp53tm1Xu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:86185
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted |
Mutation: |
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Nucleotide substitutions
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Mutation details: Site directed mutagenesis within exon 2 generated a missense mutation (AG>GC) at codon 18 resulting in the substitution of serine with alanine (p.S18A). Serine 18 corresponds with human serine 15 of TP53 and this mutation prevents phosphorylation of the residue in the encoded peptide. A single loxP site remained in intron 3 after the inserted loxP site flanked neomycin resistance gene cassette was excised via Cre-mediated recombination.
(J:86520)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trp53 Mutation: |
240 strains or lines available
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Original: |
J:86185 Chao C, et al., Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem. 2003 Oct 17;278(42):41028-33 |
All: |
4 reference(s) |
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