Mpl^hlb219
Chemically induced Allele Detail

Summary

• Symbol: Mpl^hlb219
• Name: myeloproliferative leukemia virus oncogene; heart, lung and blood, 219
• MGI ID: MGI:2680465
• Gene: Mpl Location: Chr4:118299612-118314710 bp, - strand Genetic Position: Chr4, 54.61 cM, cytoband D
• Alliance: Mpl^hlb219 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: DNA sequencing of exons from genomic DNA revealed a single point mutation in the Mpl gene at codon 40. The mutation is a T-to-C transition yielding an amino acid change from a conserved cysteine to an arginine. (J:146577)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mpl Mutation: 48 strains or lines available

References

• Original: J:82961 JAX National Heart, Lung and Blood Program for Genomic Applications (PGA), Heritable mouse mutants from the JAX NHLBI ENU Mutagenesis Program. MGI Direct Data Submission. 2003-10
• All: 8 reference(s)