Tg(rPEPCKSREBF2)788Reh
Transgene Detail

Summary

• Symbol: Tg(rPEPCKSREBF2)788Reh
• Name: transgene insertion 788, Robert E Hammer
• MGI ID: MGI:2680523
• Synonyms: Line B
• Transgene: Tg(rPEPCKSREBF2)788Reh Location: unknown
• Alliance: Tg(rPEPCKSREBF2)788Reh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(rPEPCKSREBF2)788Reh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SREBF2 (6721)

  Srebf2

  (MGI:107585)

• Mutation details: This transgene is composed of the rat Pepck promoter fused to a cDNA encoding amino acids 1-468 of human SREBP-2 followed by 2 stop codons. The 2.4 kb rat Pepck promoter is active in liver and adepose tissue. The cDNA portion encodes the 6HLH-zip domain and the NH2-terminal acidic transactivation domain. It lacks the membrane attachment domain and the COOH-terminal regulatory domain. Production of truncated product was determined by immunoblot analysis. (J:86518)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:86518 Horton JD, et al., Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest. 1998 Jun 1;101(11):2331-9
• All: 10 reference(s)