Akp3^tm1Jlm
Targeted Allele Detail

Summary

• Symbol: Akp3^tm1Jlm
• Name: alkaline phosphatase 3, intestine, not Mn requiring; targeted mutation 1, Jose Luis Millan
• MGI ID: MGI:2680530
• Synonyms: IAP^-
• Gene: Akp3 Location: Chr1:87052695-87055634 bp, + strand Genetic Position: Chr1, 44.06 cM
• Alliance: Akp3^tm1Jlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86263
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 6 were replaced with a neomycin resistance gene. Disruption of gene expression was confirmed by RT-PCR, Northern blot, Western blot, and immunohistochemistry. (J:86263)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akp3 Mutation: 35 strains or lines available

References

• Original: J:86263 Narisawa S, et al., Accelerated fat absorption in intestinal alkaline phosphatase knockout mice. Mol Cell Biol. 2003 Nov;23(21):7525-30
• All: 10 reference(s)