Gabrg2^tm2Lusc
Targeted Allele Detail

Summary

• Symbol: Gabrg2^tm2Lusc
• Name: gamma-aminobutyric acid type A receptor, subunit gamma 2; targeted mutation 2, Bernhard Luscher
• MGI ID: MGI:2680624
• Synonyms: fgamma2
• Gene: Gabrg2 Location: Chr11:41801030-41891684 bp, - strand Genetic Position: Chr11, 24.8 cM
• Alliance: Gabrg2^tm2Lusc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86221
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 8 was left flanked by single loxP sites after an frt flanked neo cassette was excised via Flp-mediated recombination. A single flp site was left immediately downstream of the 3' loxP site. (J:86221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabrg2 Mutation: 41 strains or lines available

References

• Original: J:86221 Schweizer C, et al., The gamma2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci. 2003 Oct;24(2):442-50
• All: 15 reference(s)