Hoxa3^tm3Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa3^tm3Mrc
• Name: homeobox A3; targeted mutation 3, Mario R Capecchi
• MGI ID: MGI:2680649
• Synonyms: Hoxa3^CFP
• Gene: Hoxa3 Location: Chr6:52146042-52190316 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa3^tm3Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86041
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The ECFP gene has been inserted in the second exon. This results in an in-frame fusion between the C-terminus of the Hoxa3 protein and the N-terminus of ECFP. The resulting fusion does not affect Hoxa3 function. (J:86041)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa3 Mutation: 24 strains or lines available

References

• Original: J:86041 Gaufo GO, et al., Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons. Development. 2003 Nov;130(21):5191-201
• All: 1 reference(s)