Icmt^tm1Sgy
Targeted Allele Detail

Summary

• Symbol: Icmt^tm1Sgy
• Name: isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Stephen G Young
• MGI ID: MGI:2680650
• Synonyms: Icmt -
• Gene: Icmt Location: Chr4:152381684-152391578 bp, + strand Genetic Position: Chr4, 83.02 cM
• Alliance: Icmt^tm1Sgy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67598
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1 through homologous recombination. Activity of the encoded protein was shown to be abolished in homozygous ES cells. (J:62754)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icmt Mutation: 12 strains or lines available

References

• Original: J:67598 Bergo MO, et al., Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J Biol Chem. 2001 Feb 23;276(8):5841-5
• All: 4 reference(s)