Cdk5r1^tm1Ohsh
Targeted Allele Detail

Summary

• Symbol: Cdk5r1^tm1Ohsh
• Name: cyclin dependent kinase 5, regulatory subunit 1; targeted mutation 1, Toshio Ohshima
• MGI ID: MGI:2680652
• Synonyms: p35-, p35KO
• Gene: Cdk5r1 Location: Chr11:80367849-80372010 bp, + strand Genetic Position: Chr11, 47.94 cM
• Alliance: Cdk5r1^tm1Ohsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67864
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the gene, resulting in the deletion of amino acid residues 148 to the carboxy terminus in the encoded protein. Northern and western blot analysis confirmed the complete inactivation of the gene. (J:67864)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk5r1 Mutation: 13 strains or lines available

References

• Original: J:67864 Ohshima T, et al., Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2764-9
• All: 13 reference(s)