Plcb3^tm1Dwu
Targeted Allele Detail

Summary

• Symbol: Plcb3^tm1Dwu
• Name: phospholipase C, beta 3; targeted mutation 1, Dianqing Wu
• MGI ID: MGI:2680661
• Synonyms: PLC beta3-null
• Gene: Plcb3 Location: Chr19:6931081-6951738 bp, - strand Genetic Position: Chr19, 5.1 cM, cytoband B
• Alliance: Plcb3^tm1Dwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57478
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced part of the exon encoding the X box. Western blot analysis demonstrated that no detectable protein was present in homogenates of dorsal root ganglia derived from homozygous mice. (J:57478)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Plcb3^tm1Dwu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plcb3 Mutation: 50 strains or lines available

References

• Original: J:57478 Xie W, et al., Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10385-90
• All: 20 reference(s)