Sod1^tm1Cje
Targeted Allele Detail

Summary

• Symbol: Sod1^tm1Cje
• Name: superoxide dismutase 1, soluble; targeted mutation 1, Charles J Epstein
• MGI ID: MGI:2680903
• Synonyms: SOD1^-
• Gene: Sod1 Location: Chr16:90017650-90023221 bp, + strand Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
• Alliance: Sod1^tm1Cje page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42265
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing most of exon 3 and all of exon 4 was replaced with a promoterless neomycin selection gene. A shortened transcript is expressed from this allele that splices exon 2 to exon 5. A 50% reduction in protein activity was demonstrated in tissues of heterozygous mice. Additional genetic studies and FISH analysis indicated that a duplication and translocation of flanking sequences to a different chromosome had taken place. See also Ts(12<16>)1Cje. (J:42265)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Sod1^tm1Cje

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sod1 Mutation: 39 strains or lines available

References

• Original: J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
• All: 41 reference(s)