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Nxf1Mvb1
Spontaneous Allele Detail
Summary
Symbol: Nxf1Mvb1
Name: nuclear RNA export factor 1; modifier of vibrator 1
MGI ID: MGI:2680965
Gene: Nxf1  Location: Chr19:8734467-8748274 bp, + strand  Genetic Position: Chr19, 5.5 cM, cytoband A
Alliance: Nxf1Mvb1 page
Mutation
origin
Strain of Origin:  CAST/Ei
Mutation
description
Allele Type:    Spontaneous
Mutation:    Nucleotide substitutions
 
Mutation detailsThis allele codes for a pro at amino acid residue 48 and for a gly at amino acid residue 610. Carriers of this allele suppress disruptions at other gene loci caused specifically by intron insertions of IAP elements in the sense orientation only. This effect results from a quantitative shift in RNA isoforms from high molecular weight disrupted transcripts to correctly processed wild-type transcripts. Crosses with several alleles (Pitpnavb, Eya1bor, Aiy, Axin1Fu, Dab1scm, Hrhr, Myo5ad, and a) revealed that this allele can only suppress sense-orientation insertions (Pitpnavb and Eya1bor), including at least some class D elements, such as IAPS but not class C insertions, such as MLVs. (J:86371)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nxf1 Mutation:  36 strains or lines available
References
Original:  J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory