Bmd3^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Bmd3^C3H/HeJ
• Name: bone mineral density 3; C3H/HeJ
• MGI ID: MGI:2681001
• QTL: Bmd3 Location: Chr13:20477612-20477820 bp
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• The allele confers increased femoral BMD compared to C57BL/6J. (J:85226)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58152

Bone mineral density (Bmd3) was measured as a quantitative trait (QTL) in a genome wide scan of 711 F2 mice in a genetic intercross involving C57BL/6J and CAST/Ei mice. C57BL/6J females express a low mineral bone density phenotype, alternatively CAST/Ei male express a high mineral bone density. Regression analysis was informative to show Bmd3 significantly associated with marker D13Mit16 within a defined QTL region bounded the centromere and D13Mit15. Due to the large size of the QTL region the authors did not suggest any candidate loci encoding for the Bone mineral density phenotype.

References

• Original: J:85226 Shultz KL, et al., Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density. J Bone Miner Res. 2003 Feb;18(2):175-85
• All: 1 reference(s)