Bmd13^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Bmd13^CAST/EiJ
• Name: bone mineral density 13; CAST/EiJ
• MGI ID: MGI:2681003
• QTL: Bmd13 Location: Chr13:56629249-56629397 bp Genetic Position: Chr13, cM position of peak correlated region/allele: 21.73 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased femoral BMD compared to C57BL/6J. (J:85226)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78754

Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd13 mapped to 35 cM on mouse Chromosome 13 with a peak LOD=7.73 at D13Mit13 in linkage to femoral BMD. C3H/HeJ-derived alleles confer an additively-inherited increase in BMD at Bmd13.

References

• Original: J:85226 Shultz KL, et al., Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density. J Bone Miner Res. 2003 Feb;18(2):175-85
• All: 1 reference(s)