Mmp8^tm1Otin
Targeted Allele Detail

Summary

• Symbol: Mmp8^tm1Otin
• Name: matrix metallopeptidase 8; targeted mutation 1, Carlos Lopez-Otin
• MGI ID: MGI:2681103
• Synonyms: collagenase-2 deficient, Mmp8^-, MMP-8 KO, Mmp8^tm1Lotn
• Gene: Mmp8 Location: Chr9:7558457-7568486 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Mmp8^tm1Otin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86393
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and all of exons 3 and 4 were replaced with a PGK-neomycin gene. Lack of protein product verified by immunofluorescence analysis blood neutrophils and by Western blot analysis. (J:86393)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mmp8 Mutation: 27 strains or lines available

References

• Original: J:86393 Balbin M, et al., Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet. 2003 Nov;35(3):252-7
• All: 36 reference(s)