Ncdn^tm1Afu
Targeted Allele Detail

Summary

• Symbol: Ncdn^tm1Afu
• Name: neurochondrin; targeted mutation 1, Akiyoshi Fukamizu
• MGI ID: MGI:2681104
• Gene: Ncdn Location: Chr4:126637548-126647203 bp, - strand Genetic Position: Chr4, 60.93 cM, cytoband D2.1
• Alliance: Ncdn^tm1Afu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86413
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic sequence fragment extending from within exon 3 through a portion of exon 7 was replaced with a cassette containing lacZ and neo. The deleted sequence encoded amino acids 151 through 729. LacZ expression was observed and putatively controlled via the endnogenous promoter and regulatory elements. (J:86413)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncdn Mutation: 41 strains or lines available

References

• Original: J:86413 Mochizuki R, et al., Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality. Biochem Biophys Res Commun. 2003 Oct 31;310(4):1219-26
• All: 1 reference(s)