Dpml^BALB/cJ
QTL Variant Detail

Summary

• QTL variant: Dpml^BALB/cJ
• Name: dopamine loss; BALB/cJ
• MGI ID: MGI:2681146
• QTL: Dpml Location: Chr15:51004694-76794493 bp Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: BALB/cJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased MPTP-induced dopamine depletion in female animals compared to C57BL/6J. (J:85562)
• Inheritance: Other (see notes)

Notes

Dpml exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:85562

Genome scan was performed an a population of (C57BL/6J x BALB/cJ)F2 animals to detect loci associated with MPTP-induced dopamine depletion. MPTP is a neurotoxin that causes dopamine loss and Parkinson's disease symptoms in experimental animals. Parental strain C57BL/6J exhibits increased susceptibility to MPTP-induced dopamine depletion compared to BALB/cJ. Interestingly, female F2 animals exhibit a 31.6% mortality rate after MPTP administration whereas male F2 animals exhibit 0% mortality.

Dpml (dopamine loss), a female specific locus mapped to approximately 32.5 cM on mouse Chromosome 15 with LOD=4.8 between 21 cM (D15Mit100) and 44.1 cM (D15Mit68). BALB/cJ-derived alleles confer increased MPTP-induced dopamine depletion at Dpml. A candidate gene mapping to this region is Hsf1.

A suggestive locus mapped to 30 cM (D13Mit91) - 45 cM (D13Mit233) on mouse Chromosome 13. BALB/cJ-derived alleles confer increased MPTP-induced dopamine depletion at this locus.

An interacting locus pair reaching statisticalsignificance was also identified at 29 cM on mouse Chromosome 9 and 79.4 cM on mouse Chromosome 3. Interaction occurs between D9Mit14 and D3Mit147.

References

• Original: J:85562 Sedelis M, et al., Chromosomal loci influencing the susceptibility to the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurosci. 2003 Sep 10;23(23):8247-53
• All: 1 reference(s)