Nktcn2^NOD/ShiLt
QTL Variant Detail

Summary

• QTL variant: Nktcn2^NOD/ShiLt
• Name: natural killer T cell numbers 2; NOD/ShiLt
• MGI ID: MGI:2681152
• Synonyms: Nktcn2^NOD
• QTL: Nktcn2 Location: Chr2:138737416-145893953 bp Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: NOD/ShiLt

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased natural killer T cell numbers compared to C57BL/6J.
• Inheritance: Other (see notes)

Notes

Nktcn2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:85376

Linkage analysis was performed on 138 (C57BL/6J x NOD.B6-(D6Mit105-D6Mit135))F1 x NOD.B6-(D6Mit105-D6Mit135) backcross animals to identify QTLs associated with natural killer T (NKT) cell numbers. 181 markers (90% genome coverage) at an average spacing of 8 cM were used in the genome scan. Parental strain C57BL/6J exhibits higher NKT cell numbers compared to parental strain NOD.Nkrp1^b. (C57BL/6J x NOD.B6-(D6Mit105-D6Mit135))F1 hybrid animals exhibit NKT cell numbers similar to the C57BL/6J parentals.

Nktcn1 (natural killer T cell numbers 1) was identified at 87.9 cM on mouse Chromosome 1 with LOD=6.82 at D1Mit15. Nktcn1 spans a 7 cM interval with C57BL/6J-derived alleles conferring increased NKT cell numbers with an additive mode of inheritance. Potential candidate genes mapping near Nktcn1 include Sele, Xcl1, Cd3z, Fcgr2b, Fcgr3, and Cd244.

Nktcn2 was identified at approximately 73 cM on mouse Chromosome 2 with LOD=4.9 between D2Mit490 and D2Mit280. Nktcn2 spans a 3 cM interval with C57BL/6J-derived alleles conferring increased NKT cell numbers with an additive mode of inheritance. Potential candidate genes mapping near Nktcn2 include a yet unnamed heat shock protein and B2m.

Suggestive linkages to NKT cell numbers were also observed between 15 cM(D2Mit294) and 31.7 cM (D2Mit458) on mouse Chromosome 2 with LOD=1.92, at 60 cM (D7Mit101) on mouse Chromosome 7 with LOD=1.9, and at 22.5 cM (D17Mit176) near the MHC region of mouse Chromosome 17 with LOD=2.0.

References

• Original: J:85376 Esteban LM, et al., Genetic control of NKT cell numbers maps to major diabetes and lupus Loci. J Immunol. 2003 Sep 15;171(6):2873-8
• All: 1 reference(s)