Camkk2^tm1Kpg
Targeted Allele Detail

Summary

• Symbol: Camkk2^tm1Kpg
• Name: calcium/calmodulin-dependent protein kinase kinase 2, beta; targeted mutation 1, K Peter Giese
• MGI ID: MGI:2681319
• Gene: Camkk2 Location: Chr5:122869233-122917472 bp, - strand Genetic Position: Chr5, 62.55 cM
• Alliance: Camkk2^tm1Kpg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86370
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was removed via cre mediated recombination of a single loxP site in intron 4 and the 3' loxP site of a floxed neo cassette in intron 5. The deletion of exon 5 results in the removal of sequence encoding part of the catalytic domain common to all CaM kinase kinase beta isoforms and putatively generates a frameshift mutation that leads to a premature stop codon. Protein was undetected in the forebrain and cerebellum of homozygous mutant mice by homologous recombination. (J:86370)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camkk2 Mutation: 42 strains or lines available

References

• Original: J:86370 Peters M, et al., Loss of Ca2+/calmodulin kinase kinase beta affects the formation of some, but not all, types of hippocampus-dependent long-term memory. J Neurosci. 2003 Oct 29;23(30):9752-60
• All: 5 reference(s)