Rarg^tm1Blt
Targeted Allele Detail

Summary

• Symbol: Rarg^tm1Blt
• Name: retinoic acid receptor, gamma; targeted mutation 1, Horst Bluethmann
• MGI ID: MGI:2681395
• Gene: Rarg Location: Chr15:102143373-102165891 bp, - strand Genetic Position: Chr15, 57.4 cM, cytoband E-F3
• Alliance: Rarg^tm1Blt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27473
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 8, which encodes the B-domain. RT-PCR and northern blot analysis confirmed that no functional transcript was expressed from this allele. (J:27473)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rarg Mutation: 151 strains or lines available

References

• Original: J:27473 Look J, et al., Marked resistance of RAR gamma-deficient mice to the toxic effects of retinoic acid. Am J Physiol. 1995 Jul;269(1 Pt 1):E91-8
• All: 2 reference(s)